RFI: AI-Enabled Discovery of Broad-Spectrum Small-Molecule Inhibitors for Filoviruses

Request for Information Description

The purpose of this Request for Information (RFI) is to conduct market research to identify organizations with capabilities in artificial intelligence (AI) for application in the discovery and advancement of broad-spectrum, small-molecule therapeutics targeting filoviruses (e.g., Ebola virus (EBOV), Sudan virus (SUDV), Marburg virus (MARV)).

This RFI seeks information regarding technical capabilities, infrastructure, relevant experience, and recommended approaches for the application of AI and advanced computational methodologies across the therapeutic development lifecycle. Areas of interest include AI-driven therapeutic design and optimization, in vitro validation of candidate hits, and early preclinical proof-of-concept evaluation.

Respondents do not have to be a member of the RRPV consortium to submit a response for this RFI; however, they must be a member of the consortium to respond to any future request for project proposals (RPP) for this requirement.