The ASSURE program aims to develop innovative, multiplexed, high-throughput, scalable and sample sparing assays that provide comprehensive evaluation of an individual’s immune status as a response to
either infection or vaccination.

This program seeks to de-risk the development of novel assay platform technologies with the ultimate
goal of establishing new, qualified assays primarily for BARDA and vaccine developers to comprehensively
assess the immune response and status elicited by vaccines and/or infection due to CBRN threats,
pandemic influenza, or other emerging infectious diseases. Some of these assays may lead to support of
new correlates of protection.

All RRPV submissions must be submitted to the BARDA Digital Resources (BDR) RRPV Portal. Offerors may submit, or re-submit, in advance of the deadline. Neither the Government nor the RRPV CMF will make allowances/exceptions for submission problems encountered by the Offeror using system-to-system interfaces. If the Offeror fails to submit the full submission prior to the deadline, the submission may not be accepted. It is the Offeror’s responsibility to ensure a timely and complete submission. Failure to propose your submission on time for any reason may result in the submission not being considered for award.

The account request process is simple but may take several days for approval and access. To request a BDR RRPV Portal account (first-time user), please complete this form. Once access to the BDR RRPV Portal account has been confirmed, the Offeror will log in to the Portal (www.rrpv.hhs.gov) using the prescribed two-factor authentication method. Once login is complete, the Offeror will be prompted to verify their user information and basic organization-related data. To request changes to your contact information, please contact RRPV (RRPV@ati.org). The Offeror will then be able to start a new submission and will be prompted to input the submission with other project-specific information. Offerors will be provided an automated confirmation of successful submission of a Proposal.

Documentation and reference materials for the BDR RRPV Portal are available to RRPV Member Organizations from the RRPV Members Only Site (for new users, request access here), and upon request from RRPV@ati.org.

Original RPP Release:

Issued: 14 November 2025

Due: 18 December 2025 by 1pm Eastern